| Drug induced
acceleration of metabolism of drugs |
|
Inhibition
of metabolism of a drug by another drug |
| Inducer |
Drugs whose metabolism is
accelerated |
Inhibitor |
Drugs whose metabolism is
inhibited |
| Barbiturates |
Barbiturates, oral anticoagulants,
steroids (oral contraceptives, testosterone, glucocorticoids),
vitamins (D and K), thyroxine, phenylbutazone, phenytoin, griseofulvin,
chloramphenicol, theophylline |
Allopurinol |
Tolbutamide, methotrexate, probenecid. |
| Disulfiram |
Alcohol, tolbutamide, warfarin, phenytoin. |
| Isoniazid |
Glucocorticoids, oral contraceptives, carbamazepine,
phenytoin |
| Chloramphenicol |
Tolbutamide, probenecid, phenytoin |
| Phenytoin |
Glucocorticoids, vitamin D,
theophylline |
Cimetidine |
Warfarin, diazepam |
| Ketoconazole |
Cyclosporin, astemizole,terfenadine |
| Phenylbutazone |
Phenytoin, tolbutamide. |
| Phenylbutazone |
Glucocorticoids |
Ethanol |
Methanol (beneficial effect) |
| Griseofulvin |
Warfarin |
Macrolides |
Theophylline, glucocorticoids |
| Rifampicin |
Oral contraceptives, glucocorticoids, metoprolol,
propranolol |
| Carbamazepine |
Vitamin D |
Grape fruit juice* |
Cyclosporin, terfenadine and most calcium
channel blockers |
| Dicophane and gamma benzene
hexachloride are powerful inducers of drug- metabolising microsomal
enzymes. Hence, research on drug metabolism could be misleading.
If the animal quarters are sprayed with either of these insectcides |
Many drugs inhibit the p-hydroxylation
of phenytoin, increasing the chance of phenytoin toxicity. They
inclulde dicumarol, isoniazid, sulfaphenazole, disulfiram, chloramphenicol
and methylphenydate.
* Contains psoralen |
|
