| BELLADONNA
ALKALOIDS & BARBITURATES |
Brand & Generic Names
| Antrocol |
Donna-Sed |
| ATROPINE & PHENOBARBITAL |
Donnatal |
| ATROPINE, HYOSCYAMINE, |
Donnatal Extentabs |
| SCOPOLAMINE & |
Donnatol No. 2 |
| BUTABARBITAL |
Donphen |
| ATROPINE, HYOSCYAMINE, |
HYOSCYAMINE & |
| SCOPOLAMINE & |
PHENOBARBITAL |
| PHENOBARBITAL |
Hyosophen |
| Barbidonna |
Kinesed |
| Barbidonna 2 |
Levsin-PB |
| Barophen |
Levsin with Phenobarbital |
| Belladenal |
Levsinex with Phenobarbital |
| Belladenal-S |
Timecaps |
| Belladenal Spacetabs |
Malatal |
| BELLADONNA & AMOBARBITAL |
Pheno-Bella |
| BELLADONNA & BUTABARBITAL |
Relaxadon |
| Bellalphen |
Spaslin |
| Bellergal |
Spasmolin |
| Butibel |
Spasmophen |
| Chardonna-2 |
Spasquid |
| Donnamor |
Susano |
| Donnapine |
|
Basic Information
- Habit forming? Yes
- Prescription needed? Yes
- Available as generic? Some yes, some no
- Drug class: Antispasmodic, anticholinergic, sedative
Uses
- Reduces spasms of digestive system, bladder and urethra.
- Reduces anxiety or nervous tension (low dose).
- Relieves insomnia (higher bedtime dose).
Dosage & Usage Information
How to take:
Tablet, liquid or capsule--Swallow with liquid or food to
lessen stomach irritation. If you can't swallow whole, crumble
tablet or open capsule and take with liquid or food.
Extended-release tablets or capsules-- Swallow each dose whole.
Chewable tablets--Chew well before swallowing.
Drops--Dilute dose in beverage before swallowing.
When to take:
At the same times each day.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than
2 hours, wait for next scheduled dose (don't double this dose).
What drug does:
May partially block nerve impulses at nerve-cell connections.
Blocks nerve impulses at parasympathetic nerve endings, preventing
muscle contractions and gland secretions of organs involved.
Time lapse before drug works:
15 to 30 minutes.
Don't take with:
Antacids* or antidiarrheals*.
Any other medicine without consulting your doctor or pharmacist.
Overdose
SYMPTOMS:
Blurred vision, confusion, convulsions, irregular heartbeat,
hallucinations, coma.
WHAT TO DO:
- Dial 911 (emergency) or O (operator) for an ambulance
or medical help. Then give first aid immediately.
- See EMERGENCY Information.
Possible Adverse Reactions or Side Effects
Life-threatening:
Unusual excitement, Seek emergency restlessness, fast treatment
immediately. heartbeat, breathing difficulty.
Common:
- Dry mouth, throat, nose; drowsiness; constipation; dizziness;
nausea; vomiting; "hangover" effect; depression; confusion.
- Reduced sweating, slurred speech, agitation, nasal congestion,
altered taste.
Infrequent:
Difficult urination; difficult swallowing; rash or hives;
face, lip or eyelid swelling; joint or muscle pain; lightheadedness.
Rare:
Jaundice; unusual bruising or bleeding; hives, skin rash;
pain in eyes; blurred vision; sore throat, fever, mouth sores;
unexplained bleeding or bruising.
Warnings & Precautions
Don't take if:
- You are allergic to any barbiturate or any anticholinergic.
- You have porphyria, trouble with stomach bloating, difficulty
emptying your bladder completely, narrow-angle glaucoma,
severe ulcerative colitis.
Before you start, consult your doctor:
- If you have open-angle glaucoma, angina, chronic bronchitis
or asthma, hiatal hernia, liver disease, enlarged prostate,
myasthenia gravis, peptic ulcer, epilepsy, kidney or liver
damage, anemia, chronic pain, thyroid disease.
- If you will have surgery within 2 months, including dental
surgery, requiring general or spinal anesthesia.
Over age 60:
Adverse reactions and side effects may be more frequent and
severe than in younger persons. Ask your doctor about small
doses.
Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.
Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until
you finish medicine.
Infants & children:
Use only under doctor's supervision.
Prolonged use:
- May cause addiction, anemia, chronic intoxication.
- May lower body temperature, making exposure to cold temperatures
hazardous.
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun
or sunlamp.
Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't
climb ladders or work in high places. Danger increases if
you drink alcohol or take medicine affecting alertness and
reflexes.
Discontinuing:
May be unnecessary to finish medicine. Follow doctor's instructions.
If you develop withdrawal symptoms of hallucinations, agitation
or sleeplessness after discontinuing, call doctor right away.
Others:
- Great potential for abuse.
- Advise any doctor or dentist whom you consult that you
take this medicine.
Possible Interaction with Other Drugs
| GENERIC NAME |
COMBINED EFFECT |
|
|
| ------------------------ |
----------------------- |
| Acetaminophen |
Possible decreased barbiturate |
|
effect. |
| Amantadine |
Increased belladonna effect. |
| Antacids* |
Decreased belladonna effect. |
| Anticoagulants*, |
Decreased anti- |
| oral |
coagulant effect. |
| Anticholinergics, |
Increased belladonna |
| other* |
effect. |
| Anticonvulsants* |
Changed seizure patterns. |
| Antidepressants, |
Possible dangerous |
| tricyclics (TCA)* |
oversedation. Avoid. |
| Antidiabetics*, |
Increased barbiturate |
| oral |
effect. |
| Antihistamines* |
Dangerous sedation. Avoid. |
| Aspirin |
Decreased aspirin effect. |
| Attapulgite |
Decreased belladonna effect. |
| Beta-adrenergic |
Decreased effects of |
| blockers* |
beta-adrenergic blocker. |
| Carteolol |
Increased barbiturate effect. |
|
Dangerous sedation. |
| Central nervous |
Dangerous sedation. Avoid. |
|
|
|
|
| Contraceptives*, |
Decreased contraceptive |
| oral |
effect. |
| Cortisone drugs* |
Increased internal eye pressure. |
|
Decreased cortisone effect. |
| Digitoxin |
Decreased digitoxin effect. |
| Doxycycline |
Decreased doxycycline effect. |
| Dronabinol |
Increased effects of both drugs. |
|
Avoid. |
| Furosemide |
Possible orthostatic hypotension. |
| Griseofulvin |
Decreased griseofulvin effect. |
| Haloperidol |
Increased internal eye pressure. |
| Indapamide |
Increased indapamide effect. |
| Ketoconazole |
Decreased ketoconazole effect. |
| MAO inhibitors* |
Increased belladonna and |
|
barbiturate effect. |
| Meperidine |
Increased belladonna effect. |
| Methylphenidate |
Increased belladonna effect. |
| Metronidazole |
Decreased metronidazole effect. |
| Mind-altering drugs* |
Dangerous sedation. Avoid. |
| Narcotics* |
Dangerous sedation. Avoid. |
| Nitrates* |
Increased internal eye pressure. |
| Nizatidine |
Increased nizatidine effect. |
| Non-steroidal |
Decreased anti-inflammatory effect. |
|
|
|
|
| Orphenadrine |
Increased belladonna effect. |
| Pain relievers* |
Dangerous sedation. Avoid. |
| Phenothiazines* |
Increased belladonna effect. Danger |
|
of oversedation. |
| Pilocarpine |
Loss of pilocarpine effect in |
|
glaucoma treatment. |
| Potassium |
Possible intestinal |
| supplements* |
ulcers with oral potassium tablets. |
| Quinidine |
Increased belladonna effect. |
| Sedatives* |
Dangerous sedation. Avoid. |
| Sleep inducers* |
Dangerous sedation. Avoid. |
| Sotalol |
Increased barbiturate effect. |
|
Dangerous sedation. |
| Tranquilizers* |
Dangerous sedation. Avoid. |
| Valproic acid |
Increased barbiturate effect. |
| Vitamin C |
Decreased belladonna effect. Avoid |
|
large doses of vitamin C. |
Possible Interaction with Other Substances
| INTERACTS WITH |
COMBINED EFFECT |
| --------------- |
--------------- |
| Alcohol: |
Possible fatal oversedation. Avoid. |
|
|
| Beverages: |
None expected. |
|
|
| Cocaine: |
Excessively rapid heartbeat. Avoid. |
|
|
| Foods: |
None expected. |
|
|
| Marijuana: |
Drowsiness and dry mouth. Avoid. |
|
|
| Tobacco: |
Decreased effectiveness of acid |
|
reduction in stomach. |
|
|