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ATROPINE, HYOSCYAMINE, METHENAMINE, METHYLENE BLUE

Brand & Generic Names

Atrosept Urimed
Dolsed Urinary Antiseptic No. 2
Hexalol Urised
Prosed/DS Uriseptic
Trac Tabs 2X Uritab
U-Tract Uritin
UAA Uro-Ves
Uridon Modified

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Analgesic (urinary), antispasmodic, anti-infective (urinary)

Uses

    A combination medicine to control infection, spasms and pain caused by urinary tract infections.

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.

When to take:
30 minutes before meals (unless directed otherwise by doctor).

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Makes urine acid. Blocks nerve impulses at parasympathetic nerve endings, preventing muscle contractions and gland secretions of organs involved. Methenamine destroys some germs.

Time lapse before drug works:
15 to 30 minutes.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.


Overdose

SYMPTOMS:
Dilated pupils, rapid pulse and breathing, dizziness, fever, hallucinations, confusion, slurred speech, agitation, flushed face, convulsions, coma.

WHAT TO DO:

  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

    Heartbeat irregularity, Seek emergency shortness of breath or treatment immediately. difficulty breathing.

Common:

    Dry mouth, throat, ears, nose.

Infrequent:

  • Flushed, red face; drowsiness; difficult urination; nausea and vomiting; abdominal pain; ringing or buzzing in ears; severe drowsiness; back pain; lightheadedness.
  • Headache, nasal congestion, altered taste.

Rare:

    Blurred vision; pain in eyes; skin rash, hives.

Warnings & Precautions

Don't take if:

  • You are allergic to any of the ingredients or aspirin.
  • Brain damage in child.
  • You have glaucoma.

Before you start, consult your doctor:

  • If you are on any special diet such as low-sodium.
  • If you have had a hiatal hernia, bronchitis, asthma, liver disease, stomach or duodenal ulcers.
  • If you have asthma, nasal polyps, bleeding disorder or enlarged prostate.
  • If you will have any surgery within 2 months.
  • If you have heart disease.

Over age 60:

  • Adverse reactions and side effects may be more frequent and severe than in younger persons.
  • More likely to cause hidden bleeding in stomach or intestines. Watch for dark stools.

Pregnancy:
Risk to unborn child outweighs benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid or discontinue nursing until you finish medicine.

Infants & children:
Side effects more likely. Not recommended in children under 12.

Prolonged use:
May lead to constipation or kidney damage. Request lab studies to monitor effects of prolonged use.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
May disqualify for piloting aircraft during time you take medicine.

Discontinuing:
May be unnecessary to finish medicine. Follow your symptoms and doctor's advice.

Others:

  • Salicylates can complicate surgery, pregnancy, labor and delivery, and illness.
  • Urine tests for blood sugar may be inaccurate.
  • Drink cranberry juice or eat prunes or plums to help make urine more acid.

Possible Interaction with Other Drugs

GENERIC NAME COMBINED EFFECT
------------------------ -----------------------
Allopurinol Decreased allopurinol effect.
Amantadine Increased atropine and belladonna
effect.
Antacids* Decreased salicylate and
methenamine effect.
Anticoagulants* Increased anticoagulant effect.
Abnormal bleeding.
Anticholinergics, Increased atropine and
other* belladonna effect.
Antidepressants, Increased
other* sedation.
Antidiabetics, oral* Low blood sugar.
Antihistamines* Increased atropine and hyoscyamine
effect.
Aspirin Likely salicylate toxicity.
Beta-adrenergic Decreased antihypertensive
blockers* effect.
Carbonic anhydrase Decreased
inhibitors* methenamine effect.
Cortisone drugs* Increased internal-eye pressure,
increased cortisone effect. Risk of
ulcers and stomach bleeding.
Diuretics, thiazide* Decreased urine acidity.
Furosemide Possible salicylate toxicity.
Gold compounds* Increased likelihood of kidney
damage.
Haloperidol Increased internal-eye pressure.
Indomethacin Risk of stomach bleeding and
ulcers.
Ketoconazole Reduced ketoconazole effect.
MAO inhibitors* Increased belladonna and atropine
effect.
Meperidine Increased atropine and hyoscyamine
effect.
Methylphenidate Increased atropine and hyoscyamine
effect.
Minoxidil Decreased minoxidil effect.
Non-steroidal Risk of stomach
anti-inflammatory bleeding and ulcers.
Orphenadrine Increased atropine and hyoscyamine
effect.
Oxprenolol Decreased antihypertensive effect
of oxprenolol.
Para-aminosalicylic Possible salicylate
acid (PAS) toxicity.
Penicillins* Increased effect of both drugs.
Phenobarbital Decreased salicylate effect.
Phenothiazines* Increased atropine and hyoscyamine
effect.
Phenytoin Increased phenytoin effect.
Pilocarpine Loss of pilocarpine effect in
glaucoma treatment.
Potassium Possible intestinal
supplements* ulcers with oral potassium tablets.
Probenecid Decreased probenecid effect.
Propranolol Decreased salicylate effect.
Rauwolfia alkaloids* Decreased salicylate effect.
Salicylates, other* Likely salicylate toxicity.
Sedatives* or central Increased sedative effect of
nervous system (CNS) both drugs.
Sodium bicarbonate Decreased methenamine effect.
Spironolactone Decreased spironolactone effect.
Sulfa drugs* Possible kidney damage.
Sulfinpyrazone Decreased sulfinpyrazone effect.
Terfenadine May conceal symptoms of salicylate
overdose, such as ringing in ears.
Vitamin C (1 to 4 Increased effect of
grams per day) methenamine, contributing to urine
acidity; decreased atropine effect;
possible salicylate toxicity.

Possible Interaction with Other Substances

INTERACTS WITH COMBINED EFFECT
--------------- ---------------
Alcohol: Excessive sedation. Possible
stomach irritation and bleeding.
Avoid.
Beverages: None expected.
Cocaine: Excessively rapid heartbeat. Avoid.
Foods: None expected.
Marijuana: Drowsiness and dry mouth. May slow
body's recovery.
Tobacco: Dry mouth.

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