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AMINOSALICYLATE SODIUM

Brand & Generic Names

Nemasol-Sodium
P.A.S.
Tubasal

Basic Information

  • Habit forming? No
  • Prescription needed? Yes
  • Available as generic? No
  • Drug class: Antitubercular

Uses

    Treatment for tuberculosis (TB).

Dosage & Usage Information

How to take:
Tablet--Swallow with liquid or food to lessen stomach irritation.
Powder--Dissolve dose in water. Stir well and drink all liquid.

When to take:
At the same times each day.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Prevents growth of TB germs.
Makes TB germs more susceptible to other antituberculosis drugs.

Time lapse before drug works:
6 months.

Don't take with:
Any other medicine without consulting your doctor or pharmacist


Overdose

SYMPTOMS:
Nausea, vomiting, diarrhea; rapid breathing; convulsions.

WHAT TO DO:

  • Dial 911 (emergency) or O (operator) for an ambulance or medical help. Then give first aid immediately.
  • See EMERGENCY Information.

Possible Adverse Reactions or Side Effects

Life-threatening:

    In case of overdose, see Overdose section.

Common:

  • Painful urination, chills, low back pain, nausea, vomiting.
  • Diarrhea or abdominal pain.

Infrequent:

  • Confusion, blood in urine.
  • Headache; itchy, dry, puffy skin; rash; light sensitivity; sore throat; fever; swelling in front of neck; decreased sex drive in men; fatigue; weakness.
  • Menstrual irregularities, weight gain.

Rare:

    Jaundice.

Warnings & Precautions

Don't take if:

  • You are allergic to aminosalicylate sodium, aspirin or other salicylates.
  • Tablets have turned brownish or purplish.

Before you start, consult your doctor:

  • If you have ulcers in stomach or duodenum.
  • If you have liver or kidney disease.
  • If you have epilepsy.
  • If you have adrenal insufficiency.
  • If you have heart disease or congestive heart failure.
  • If you have cancer.
  • If you have overactive thyroid.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
No proven problems. Consult doctor.

Infants & children:
Use only under medical supervision.

Prolonged use:

  • Enlarged thyroid gland and decreased function.
  • Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check liver function, kidney function.

Skin & sunlight:
Increased sensitivity to light.

Driving, piloting or hazardous work:
No problems expected.

Discontinuing:
No problems expected.

Others:

  • Treatment may need to continue for several years or indefinitely.
  • Periodic blood tests and liver and kidney function studies recommended.

Possible Interaction with Other Drugs

GENERIC NAME COMBINED EFFECT
------------------------ -----------------------
Aminobenzoic acid Decreased effect of
(PABA) aminosalicylate sodium.
Anticoagulants, Increased anti-
oral* coagulant effect.
Anticonvulsants, Increased anti-
hydantoin* convulsant effect.
Aspirin Stomach irritation.
Barbiturates* Oversedation.
Folic acid Decreased effect of folic acid.
Probenecid Increased aminosalicylate sodium
effect. Possible toxicity.
Rifampin Decreased rifampin effect.
Sulfa drugs* Decreased effect of sulfa drugs.
Sulfinpyrazone Increased aminosalicylate sodium
effect. Possible toxicity.
Tetracyclines* Reduced absorption of
aminosalicylate sodium. Space
doses 3 hours apart.
Vitamin B-12 Decreased absorption of
vitamin B-12.

Possible Interaction with Other Substances

INTERACTS WITH COMBINED EFFECT
--------------- ---------------
Alcohol: Possible liver disease.
Beverages: None expected
Cocaine: None expected.
Foods: None expected.
Marijuana: None expected.
Tobacco: None expected, but tobacco smoking
may slow recovery. Avoid.

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